SCHEMBL2365946

SCHEMBL2365946

Cc1ccc(C(=O)C2CCN(C(=O)c3ccc(N4CCOC4=O)cc3)CC2)cc1

nearest known ligand 0.68

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.68
KMT2A Q03164 4/20 0.68
MGLL Q99685 8/20 0.61
HSD11B1 P28845 6/20 0.61
ALDH1A1 P00352 1/20 0.59
LMNA P02545 1/20 0.59
POLB P06746 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2366063 0.89 MGLL (0.68) MEN1KMT2AMGLLHSD11B1
SCHEMBL2366364 0.84 MEN1 (0.58) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2366367 0.83 KMT2A (0.49) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL6235216 0.83 MEN1 (1.00) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2366269 0.80 MEN1 (0.65) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2366277 0.80 MEN1 (0.65) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL1720669 0.78 MEN1 (0.88) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2366856 0.78 MEN1 (0.61) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2366852 0.78 MEN1 (0.61) MEN1KMT2AMGLLHSD11B1ALDH1A1
SCHEMBL2535612 0.77 DGAT1 (0.51) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364975-B1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORP (JP) 2013-06-12 EP disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
EP-2364975-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2011-09-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP2 MEN1 2896/4885KMT2A 800/4885MGLL 2163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.