Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Larazotide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 7/20 | 0.41 |
| ▸ | NPY4R | P50391 | 7/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.41 |
| ▸ | NPY1R | P25929 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TFPI | P10646 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Larazotide SCHEMBL28795844 | 1.00 | CAPN1 (0.43) | CAPN1STAT3NTSR1NPY2RNPY4R | |
| Larazotide SCHEMBL23668120 | 1.00 | CAPN1 (0.43) | CAPN1STAT3NTSR1NPY2RNPY4R | |
| Larazotide SCHEMBL29366234 | 0.98 | CAPN1 (0.42) | CAPN1STAT3NTSR1NPY2RNPY4R | |
| SCHEMBL30286103 | 0.96 | CAPN1 (0.43) | CAPN1STAT3NTSR1NPY2RNPY4R | |
| SCHEMBL29568037 | 0.91 | CAPN1 (0.42) | CAPN1STAT3NTSR1OPRD1 | |
| SCHEMBL30197449 | 0.89 | CAPN1 (0.44) | CAPN1STAT3NTSR1NPY2RNPY4R | |
| SCHEMBL30539771 | 0.86 | CTSD (0.42) | CAPN1STAT3NTSR1CTSDBACE1 | |
| SCHEMBL29566935 | 0.86 | OPRD1 (0.41) | CAPN1NTSR1OPRD1 | |
| SCHEMBL29567235 | 0.86 | NTSR1 (0.40) | CAPN1STAT3NTSR1OPRD1 | |
| SCHEMBL29567365 | 0.86 | NTSR1 (0.40) | CAPN1STAT3NTSR1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114832088-A | Application of Larazolid polypeptide in preparation of medicines for relieving adriamycin cardiotoxicity | 李臻 | 2022-08-02 | — | — | CN | claimed |
| US-20240293473-A1 | METHODS FOR DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES | Tets, Viktor Veniaminovich (US) | 2024-09-05 | — | — | US | disclosed |
| US-11918610-B2 | Methods for diagnosis and treatment of type 1 diabetes | Tets, Viktor Veniaminovich (US) | 2024-03-05 | — | — | US | disclosed |
| EP-4326304-A1 | ZONULIN ANTAGONISTS FOR THE TREATMENT OF MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) AND ADULTS (MIS-A) | Ebris S.r.l. (IT) | 2024-02-28 | — | — | EP | disclosed |
| CN-114832088-A | Application of Larazolid polypeptide in preparation of medicines for relieving adriamycin cardiotoxicity | 李臻 | 2022-08-02 | — | — | CN | disclosed |
| US-20210275600-A1 | METHODS FOR DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES | Tets, Viktor Veniaminovich (US) | 2021-09-09 | — | — | US | disclosed |
| EP-3852774-A1 | METHODS FOR DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES | Tets, Viktor, Veniaminovich (US) | 2021-07-28 | — | — | EP | disclosed |