Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16423195 | 0.79 | L3MBTL1 (0.47) | CTSBSMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL23671577 | 0.78 | L3MBTL1 (0.48) | CTSBGPR35SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL6612675 | 0.74 | ALDH1A1 (0.44) | GPR35SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL2655331 | 0.68 | HSP90AA1 (0.59) | ALDH1A1L3MBTL1HSP90AA1 | |
| SCHEMBL3913610 | 0.67 | L3MBTL1 (0.44) | SMN1; SMN2ALDH1A1HTTL3MBTL1AKR1C3 | |
| SCHEMBL23671554 | 0.67 | SMN1; SMN2 (0.38) | CTSBSMN1; SMN2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL30683847 | 0.67 | GPR35 (0.45) | GPR35SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL1769433 | 0.66 | TSHR (0.47) | ALDH1A1TSHRMAPK1LMNAMAPT | |
| SCHEMBL2388988 | 0.66 | ALDH1A1 (0.66) | CTSBSMN1; SMN2ALDH1A1HPGDMAPK1 | |
| SCHEMBL23671539 | 0.66 | ALDH1A1 (0.39) | CTSBSMN1; SMN2ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | UCBBiopharma Srl (BE) | 2022-10-04 | — | — | US | disclosed |
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2021-07-29 | — | — | US | disclosed |
| CN-112334192-A | Spirocyclic indane analogs as IL-17 modulators | UCB生物制药有限责任公司 | 2021-02-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | IL17A, IL18, IL23R | CTSB 3720/4885GPR35 441/4885SMN1; SMN2 4236/4885 |
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | IL17A, IL18, IL23R | CTSB 3720/4885GPR35 441/4885SMN1; SMN2 4236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.