Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904809 | 0.79 | L3MBTL1 (0.64) | L3MBTL1SMN1; SMN2HDAC1MAPK1ALDH1A1 | |
| SCHEMBL23671510 | 0.78 | CTSB (0.46) | L3MBTL1SMN1; SMN2CTSBGPR35MAPK1 | |
| SCHEMBL17241125 | 0.76 | CYP1A2 (0.49) | L3MBTL1SMN1; SMN2GPR35MAPK1ALDH1A1 | |
| SCHEMBL30683847 | 0.75 | GPR35 (0.45) | L3MBTL1SMN1; SMN2GPR35MAPK1ALDH1A1 | |
| SCHEMBL8097310 | 0.73 | CYP1A2 (0.47) | SMN1; SMN2GPR35MAPK1ALDH1A1TP53 | |
| SCHEMBL22832642 | 0.72 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1TP53 | |
| SCHEMBL20588981 | 0.72 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2GPR35HDAC1MAPK1 | |
| SCHEMBL27491469 | 0.69 | HSD17B10 (0.47) | SMN1; SMN2MAPK1ALDH1A1TP53TSHR | |
| SCHEMBL23671545 | 0.68 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1TP53HPGDMAPT | |
| SCHEMBL23671554 | 0.67 | SMN1; SMN2 (0.38) | L3MBTL1SMN1; SMN2CTSBMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | UCBBiopharma Srl (BE) | 2022-10-04 | — | — | US | disclosed |
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2021-07-29 | — | — | US | disclosed |
| CN-112334192-A | Spirocyclic indane analogs as IL-17 modulators | UCB生物制药有限责任公司 | 2021-02-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210228547-A1 | Spirocyclic Indane Analogues as IL-17 Modulators | IL17A, IL18, IL23R | L3MBTL1 4675/4885SMN1; SMN2 4236/4885CTSB 3720/4885 |
| US-11458124-B2 | Spirocyclic indane analogues as IL-17 modulators | IL17A, IL18, IL23R | L3MBTL1 4675/4885SMN1; SMN2 4236/4885CTSB 3720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.