Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 4/20 | 0.46 |
| ▸ | PLAU | P00749 | 4/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 15/20 | 0.44 |
| ▸ | MMP13 | P45452 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23693947 | 0.96 | USP2 (0.51) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL6772621 | 0.95 | USP2 (0.49) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23673499 | 0.89 | MMP12 (0.42) | USP2HTTSMN1; SMN2PLAUPLAT | |
| SCHEMBL6772598 | 0.87 | HTT (0.55) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL6771478 | 0.85 | MMP1 (0.47) | MMP12MMP13MMP2MMP3MMP9 | |
| Hydroxyamine SCHEMBL7578513 | 0.85 | HTT (0.53) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23693537 | 0.85 | MMP12 (0.42) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL7065810 | 0.84 | SMN1; SMN2 (0.55) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23693960 | 0.84 | POLB (0.42) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23673475 | 0.81 | MMP12 (0.64) | USP2HTTSMN1; SMN2PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021147882-A1 | DIBENZOFURAN DERIVATIVE CATHEPSIN K INHIBITOR, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-07-29 | — | — | WO | disclosed |
| WO-2021147882-A1 | DIBENZOFURAN DERIVATIVE CATHEPSIN K INHIBITOR, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-07-29 | — | — | WO | disclosed |