Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.47 |
| ▸ | MMP13 | P45452 | 17/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772621 | 0.90 | USP2 (0.49) | MMP13MMP2MMP3MMP9MMP12 | |
| SCHEMBL23693947 | 0.89 | USP2 (0.51) | MMP13MMP2MMP3MMP9MMP12 | |
| SCHEMBL23693537 | 0.87 | MMP12 (0.42) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL23693158 | 0.86 | POLB (0.42) | MMP1MMP13MMP12 | |
| SCHEMBL23673553 | 0.85 | USP2 (0.51) | MMP13MMP2MMP3MMP9MMP12 | |
| SCHEMBL6771108 | 0.85 | MMP1 (0.51) | MMP1MMP13ADAM17 | |
| SCHEMBL23673499 | 0.82 | MMP12 (0.42) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL23693960 | 0.82 | POLB (0.42) | MMP1MMP13MMP12 | |
| SCHEMBL6771228 | 0.79 | MMP1 (0.50) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL6778949 | 0.78 | MMP1 (0.49) | MMP1MMP13ADAM17MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677355-B1 | DIBENZOFURAN-3-(SULFONYLAMINO OR SULFINAMINO) DERIVATIVES; MULTIPLE SCLEROSIS, ATHEROSCLEROSIS, HEART FAILURE, PERIODONTAL DISEASE, OSTEOARTHRITIS, AUTOIMMUNE DISEASE; ANTICARCINOGENIC AGENTS | WARNER-LAMBERT COMPANY | 2004-01-13 | — | — | US | claimed |