Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 4/20 | 0.48 |
| ▸ | PLAU | P00749 | 4/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 13/20 | 0.42 |
| ▸ | MMP13 | P45452 | 12/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23693947 | 0.99 | USP2 (0.51) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23673553 | 0.95 | USP2 (0.51) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL6771478 | 0.90 | MMP1 (0.47) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL23693537 | 0.88 | MMP12 (0.42) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL7065810 | 0.85 | SMN1; SMN2 (0.55) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23673499 | 0.83 | MMP12 (0.42) | USP2HTTSMN1; SMN2PLAUPLAT | |
| SCHEMBL6772598 | 0.83 | HTT (0.55) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL23693158 | 0.83 | POLB (0.42) | USP2HTTSMN1; SMN2PLGPLAU | |
| SCHEMBL6417494 | 0.82 | MMP12 (0.56) | USP2HTTSMN1; SMN2MMP12MMP13 | |
| Hydroxyamine SCHEMBL7578513 | 0.81 | HTT (0.53) | USP2HTTSMN1; SMN2PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210326-B1 | HYDROXAMIC ACID COMPOUNDS USEFUL AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER LAMBERT CO (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6677355-B1 | DIBENZOFURAN-3-(SULFONYLAMINO OR SULFINAMINO) DERIVATIVES; MULTIPLE SCLEROSIS, ATHEROSCLEROSIS, HEART FAILURE, PERIODONTAL DISEASE, OSTEOARTHRITIS, AUTOIMMUNE DISEASE; ANTICARCINOGENIC AGENTS | WARNER-LAMBERT COMPANY | 2004-01-13 | — | — | US | disclosed |