Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.56 |
| ▸ | CA2 | P00918 | 9/20 | 0.56 |
| ▸ | CA9 | Q16790 | 5/20 | 0.56 |
| ▸ | CA12 | O43570 | 5/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367468 | 0.90 | HTR6 (0.49) | CA1CA2CA9CA12CA3 | |
| SCHEMBL2367251 | 0.90 | KEAP1 (0.54) | CA1CA2CA9CA12CA3 | |
| SCHEMBL2367599 | 0.89 | RECQL (0.51) | CRBNKEAP1NFE2L2ALDH1A1KDM4E | |
| SCHEMBL2367619 | 0.88 | ALDH1A1 (0.56) | CA1CA2CA9CA12CA3 | |
| SCHEMBL2367618 | 0.86 | KEAP1 (0.57) | KEAP1NFE2L2ALDH1A1LMNAPKM | |
| SCHEMBL2368052 | 0.85 | MAPT (0.48) | CA1CA2CA9CA12CA3 | |
| SCHEMBL5948453 | 0.82 | CA1 (0.45) | CA1CA2CA9CA12CA7 | |
| SCHEMBL13948928 | 0.80 | CA1 (0.72) | CA1CA2CA9CA12CA3 | |
| SCHEMBL2367721 | 0.78 | KEAP1 (0.44) | KEAP1NFE2L2ALDH1A1LMNAPKM | |
| SCHEMBL2367200 | 0.78 | CLK1 (0.53) | CA1CA2CRBNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366687-B1 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO LTD (CN) | 2015-11-04 | — | — | EP | disclosed |
| US-8173693-B2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2012-05-08 | — | — | US | disclosed |
| CN-102199148-A | Benzenesulfonamide derivatives and pharmaceutical compositions thereof | PURZER PHARMACEUTICAL CO LTD | 2011-09-28 | — | — | CN | disclosed |
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2011-09-22 | — | — | US | disclosed |
| EP-2366687-A2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | Purzer Pharmaceutical Co., Ltd. (CN) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | CCNI, CCNE1, CCND1 | CA1 2247/4885CA2 1551/4885CA9 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.