Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 3/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367251 | 0.87 | KEAP1 (0.54) | MAPTLMNABRD4MEN1KMT2A | |
| SCHEMBL2367599 | 0.86 | RECQL (0.51) | MAPTLMNABRD4MEN1KMT2A | |
| SCHEMBL2367596 | 0.85 | CA1 (0.56) | LMNAALDH1A1CA12CA2CA9 | |
| SCHEMBL2367619 | 0.85 | ALDH1A1 (0.56) | LMNABRD4ALDH1A1CA12CA2 | |
| SCHEMBL2367468 | 0.85 | HTR6 (0.49) | MAPTLMNABRD4MEN1KMT2A | |
| SCHEMBL2367609 | 0.83 | GAA (0.53) | MAPTNFKBIARELAMEN1KMT2A | |
| SCHEMBL2367618 | 0.83 | KEAP1 (0.57) | MAPTLMNAKMT2AALDH1A1HPGD | |
| SCHEMBL2368011 | 0.82 | CYP2C9 (0.44) | MAPTLMNANFKBIARELAMEN1 | |
| SCHEMBL5948450 | 0.80 | MAPT (0.48) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL26844395 | 0.76 | LMNA (0.50) | MAPTLMNACYTH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366687-B1 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO LTD (CN) | 2015-11-04 | — | — | EP | disclosed |
| US-8173693-B2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2012-05-08 | — | — | US | disclosed |
| US-8173693-B2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2012-05-08 | — | — | US | disclosed |
| CN-102199148-A | Benzenesulfonamide derivatives and pharmaceutical compositions thereof | PURZER PHARMACEUTICAL CO LTD | 2011-09-28 | — | — | CN | disclosed |
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2011-09-22 | — | — | US | disclosed |
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2011-09-22 | — | — | US | disclosed |
| EP-2366687-A2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | Purzer Pharmaceutical Co., Ltd. (CN) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | CCNI, CCNE1, CCND1 | MAPT 3875/4885LMNA 1894/4885NFKBIA 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.