Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NFKBIA | P25963 | 3/20 | 0.53 |
| ▸ | RELA | Q04206 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368052 | 0.83 | MAPT (0.48) | SMN1; SMN2NFKBIARELAMEN1KMT2A | |
| SCHEMBL2367599 | 0.80 | RECQL (0.51) | GAASMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL2367251 | 0.79 | KEAP1 (0.54) | SMN1; SMN2PKMMEN1KMT2AOPRK1 | |
| SCHEMBL26844388 | 0.78 | SMN1; SMN2 (0.56) | GAASMN1; SMN2NFKBIARELAPKM | |
| SCHEMBL5949192 | 0.78 | MAPT (0.51) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2367596 | 0.77 | CA1 (0.56) | PKMALDH1A1CA1CA2 | |
| SCHEMBL2367619 | 0.77 | ALDH1A1 (0.56) | GAASLC40A1ALDH1A1L3MBTL1CA1 | |
| SCHEMBL2367468 | 0.77 | HTR6 (0.49) | SMN1; SMN2PKMMEN1KMT2ATDP1 | |
| SCHEMBL2367618 | 0.75 | KEAP1 (0.57) | GAASMN1; SMN2PKMKMT2ASLC40A1 | |
| SCHEMBL22428330 | 0.74 | CRBN (0.59) | GAASMN1; SMN2NFKBIARELAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366687-B1 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO LTD (CN) | 2015-11-04 | — | — | EP | disclosed |
| US-8173693-B2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2012-05-08 | — | — | US | disclosed |
| US-8173693-B2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2012-05-08 | — | — | US | disclosed |
| CN-102199148-A | Benzenesulfonamide derivatives and pharmaceutical compositions thereof | PURZER PHARMACEUTICAL CO LTD | 2011-09-28 | — | — | CN | disclosed |
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2011-09-22 | — | — | US | disclosed |
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | PURZER PHARMACEUTICAL CO., LTD. (TW) | 2011-09-22 | — | — | US | disclosed |
| EP-2366687-A2 | Benzenesulfonamide derivatives and pharmaceutical composition thereof | Purzer Pharmaceutical Co., Ltd. (CN) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230651-A1 | Benzenesulfonamide derivatives and pharmaceutical composition therof | CCNI, CCNE1, CCND1 | GAA 1759/4885SMN1; SMN2 3325/4885NFKBIA 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.