Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680976 | 0.78 | ALDH1A1 (0.56) | MAPTSMN1; SMN2ALDH1A1PKMPOLB | |
| SCHEMBL3068698 | 0.78 | PTGS2 (0.54) | USP2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL23680978 | 0.76 | ALDH1A1 (0.53) | MAPTSMN1; SMN2ALDH1A1PKMPOLB | |
| SCHEMBL475628 | 0.74 | ALPL (0.51) | MAPTSMN1; SMN2USP2ALDH1A1POLB | |
| SCHEMBL19320830 | 0.73 | PTGER1 (0.44) | USP2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL475505 | 0.73 | TTR (0.57) | USP2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2281070 | 0.73 | CYP2C19 (0.70) | MAPTALDH1A1PKMPOLBTSHR | |
| SCHEMBL13543488 | 0.72 | ALDH1A1 (0.69) | MAPTSMN1; SMN2ALDH1A1PKMPOLB | |
| SCHEMBL3071028 | 0.68 | TTR (0.46) | USP2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16195147 | 0.67 | DHODH (0.51) | SMN1; SMN2USP2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021150871-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS WITH RIPK1/RIPK3 INHIBITORS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-07-29 | — | — | WO | disclosed |