Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680978 | 0.86 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAHPGDNPC1 | |
| SCHEMBL23680979 | 0.78 | MAPT (0.47) | ALDH1A1MAPTLMNAHPGDNPC1 | |
| SCHEMBL31014207 | 0.77 | ALDH1A1 (0.75) | ALDH1A1MAPTLMNAHPGDNPC1 | |
| SCHEMBL2281070 | 0.76 | CYP2C19 (0.70) | ALDH1A1MAPTAKR1C3HTTTSHR | |
| SCHEMBL13543488 | 0.76 | ALDH1A1 (0.69) | ALDH1A1MAPTLMNAHPGDNPC1 | |
| SCHEMBL7157751 | 0.75 | RXRA (0.68) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL16195442 | 0.70 | RXRA (0.60) | NPC1RAB9ASMN1; SMN2KDM4EAKR1C3 | |
| SCHEMBL11106998 | 0.69 | ALDH1A1 (0.79) | ALDH1A1LMNASMN1; SMN2AKR1C3TSHR | |
| SCHEMBL7658881 | 0.69 | MAPT (1.00) | MAPTSMN1; SMN2KDM4EPKMMEN1 | |
| SCHEMBL6567085 | 0.68 | MAPK1 (0.81) | ALDH1A1MAPTLMNAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021150871-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS WITH RIPK1/RIPK3 INHIBITORS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-07-29 | — | — | WO | disclosed |