Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | PPM1D | O15297 | 2/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9005566 | 0.84 | PPM1D (0.64) | GRIK1FOLH1PPM1DKMOMRGPRX4 | |
| SCHEMBL9005670 | 0.84 | PPM1D (0.64) | GRIK1FOLH1PPM1DKMOMRGPRX4 | |
| SCHEMBL17982795 | 0.82 | GRIK1 (0.46) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| SCHEMBL1633286 | 0.82 | GBA1 (0.60) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| SCHEMBL29668711 | 0.80 | FOLH1 (0.51) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| SCHEMBL23684186 | 0.80 | SLC7A5 (0.51) | PPM1DMRGPRX4OPRM1OPRD1OPRK1 | |
| SCHEMBL3150745 | 0.80 | FOLH1 (0.54) | GRIK1FOLH1MRGPRX4CYP2D6CYP2C9 | |
| SCHEMBL12725438 | 0.79 | MEN1 (0.50) | GRIK1FOLH1CYP2D6CYP2C9HIF1A | |
| SCHEMBL15830232 | 0.78 | PRMT5 (0.51) | FOLH1PPM1DKMOMRGPRX4HIF1A | |
| SCHEMBL5732970 | 0.77 | LMNA (0.38) | MRGPRX4OPRM1OPRD1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11986471-B2 | Compounds and methods of use | TANGO THERAPEUTICS, INC. (US) | 2024-05-21 | — | — | US | disclosed |
| US-20230060499-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| US-20230060499-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| US-11077101-B1 | Compounds and methods of use | TANGO THERAPEUTICS, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-11077101-B1 | Compounds and methods of use | TANGO THERAPEUTICS, INC. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11986471-B2 | Compounds and methods of use | XDH, F12, LPXN | GRIK1 2217/4885FOLH1 3306/4885PPM1D 2026/4885 |
| US-11077101-B1 | Compounds and methods of use | XDH, F12, LPXN | GRIK1 2217/4885FOLH1 3306/4885PPM1D 2026/4885 |
| US-20230060499-A1 | COMPOUNDS AND METHODS OF USE | XDH, F12, LPXN | GRIK1 2217/4885FOLH1 3306/4885PPM1D 2026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.