Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | PPM1D | O15297 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974021 | 0.87 | OPRM1 (0.56) | GBA1GRIK1ITGB3ITGA2BOPRM1 | |
| Hydrochloric Acid SCHEMBL6393378 | 0.85 | OPRM1 (0.55) | GBA1GRIK1ITGB3ITGA2BOPRM1 | |
| SCHEMBL9005670 | 0.84 | PPM1D (0.64) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| SCHEMBL9005566 | 0.84 | PPM1D (0.64) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| SCHEMBL17595529 | 0.83 | LOXL2 (0.55) | GBA1PPM1DMRGPRX4HIF1ASMYD3 | |
| SCHEMBL6399782 | 0.83 | L3MBTL1 (0.54) | ITGB3ITGA2BSMYD3 | |
| SCHEMBL23684547 | 0.82 | GRIK1 (0.51) | GRIK1FOLH1PPM1DMRGPRX4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6399092 | 0.82 | L3MBTL1 (0.53) | ITGB3ITGA2BSMYD3 | |
| SCHEMBL6260511 | 0.81 | GBA1 (0.62) | GBA1GRIK1 | |
| Hydrochloric Acid SCHEMBL6153782 | 0.80 | GBA1 (0.61) | GBA1GRIK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932247-B2 | M3 muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2011-04-26 | — | — | US | disclosed |
| US-20090149447-A1 | Novel M3 Muscarinic Acetylcholine Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2009-06-11 | — | — | US | disclosed |
| EP-1957075-A2 | NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-08-20 | — | — | EP | disclosed |
| WO-2006055553-A2 | NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149447-A1 | Novel M3 Muscarinic Acetylcholine Receptor Antagonists | CHRM3, CHRM2, CHRNA3 | GBA1 4021/4885GRIK1 102/4885FOLH1 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.