Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 3/20 | 0.64 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9005566 | 1.00 | PPM1D (0.64) | PPM1DKMOCYP2D6CYP2C9HIF1A | |
| SCHEMBL31277233 | 0.86 | NPC1 (0.56) | PPM1DCYP2C9EPHX1PLAU | |
| SCHEMBL28242711 | 0.86 | OPRM1 (0.59) | PPM1DEPHX1OPRM1OPRD1OPRK1 | |
| SCHEMBL23684547 | 0.84 | GRIK1 (0.51) | PPM1DKMOCYP2D6CYP2C9HIF1A | |
| SCHEMBL1633286 | 0.84 | GBA1 (0.60) | PPM1DCYP2D6CYP2C9HIF1AGRIK1 | |
| SCHEMBL6950371 | 0.83 | ERCC5 (0.51) | PPM1DOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL2197741 | 0.82 | PPM1D (0.53) | PPM1DKMOCYP2D6CYP2C9HIF1A | |
| SCHEMBL12725438 | 0.82 | MEN1 (0.50) | CYP2D6CYP2C9HIF1AGRIK1FOLH1 | |
| SCHEMBL11228193 | 0.80 | KMT2A (0.58) | PPM1DGRIK1EPHX1 | |
| SCHEMBL17982795 | 0.79 | GRIK1 (0.46) | PPM1DCYP2D6CYP2C9HIF1AGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579223-B1 | Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity | MITSUBISHI CHEM CORP (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5385917-A | Treating androgen dependent diseases | MITSUBISHI KASEI CORPORATION (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0579223-A1 | Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity | Mitsubishi Chemical Corporation (JP) | 1994-01-19 | — | — | EP | disclosed |