SCHEMBL23699728

SCHEMBL23699728

CCS(=O)(=O)OC1CN(c2cccc(F)c2N2CCOCC2)C(=O)O1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.41
GRM2 Q14416 1/20 0.41
MAOA P21397 4/20 0.38
LMNA P02545 2/20 0.37
PTGS1 P23219 1/20 0.37
CALML3 P27482 1/20 0.37
SDHA P31040 1/20 0.37
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
P2RX7 Q99572 2/20 0.35
AKT1 P31749 2/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
HTR7 P34969 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15141811 0.82 ALDH1A1 (0.39) MAOBGRM2MAOALMNAPTGS1
SCHEMBL14696869 0.80 MAOB (0.47) MAOBGRM2MAOALMNAPTGS1
SCHEMBL12006612 0.80 MAOB (0.64) MAOBMAOALMNAPTGS1CALML3
SCHEMBL12006609 0.80 MAOB (0.64) MAOBMAOALMNAPTGS1CALML3
SCHEMBL28109902 0.79 MAOB (0.43) MAOBGRM2MAOALMNAPTGS1
SCHEMBL5513931 0.79 F10 (0.51) MAOBGRM2MAOALMNAPTGS1
SCHEMBL2401267 0.79 F10 (0.51) MAOBGRM2MAOALMNAPTGS1
SCHEMBL2401271 0.79 F10 (0.51) MAOBGRM2MAOALMNAPTGS1
SCHEMBL5250497 0.78 GRM2 (0.43) MAOBGRM2MAOALMNAPTGS1
Bromide SCHEMBL2863293 0.78 F10 (0.50) MAOBGRM2MAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11608320-B2 Oxazolidinone hydroxamic acid derivatives KUWAIT UNIVERSITY (KW) 2023-03-21 US disclosed
US-20210238151-A1 OXAZOLIDINONE HYDROXAMIC ACID DERIVATIVES KUWAIT UNIVERSITY (KW) 2021-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238151-A1 OXAZOLIDINONE HYDROXAMIC ACID DERIVATIVES ALOX5, ALOX15, ALOX15B MAOB 379/4885GRM2 1343/4885MAOA 254/4885
US-11608320-B2 Oxazolidinone hydroxamic acid derivatives ALOX5, ALOX15, ALOX15B MAOB 375/4885GRM2 1350/4885MAOA 251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.