SCHEMBL23704137

SCHEMBL23704137

Cc1c(C2CCOCC2)[nH]c2ccc(CNC(=O)c3cnc(C(F)(F)F)nc3)cc12

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ P2RX3 P56373 8/20 0.47
▸ P2RX2 Q9UBL9 8/20 0.47
▸ MAPK1 P28482 3/20 0.42
▸ NAMPT P43490 1/20 0.39
▸ MAPT P10636 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23707303 0.89 NAMPT (0.40) P2RX3P2RX2MAPK1NAMPTMAPT
SCHEMBL23704132 0.86 UCHL1 (0.44) P2RX3P2RX2MAPK1NAMPTMAPT
SCHEMBL23707327 0.83 MAPK1 (0.37) P2RX3P2RX2MAPK1NAMPT
SCHEMBL29994149 0.83 MAPK1 (0.40) MAPK1NAMPTMAPTKDM4EALDH1A1
SCHEMBL23707316 0.83 MAPK1 (0.40) MAPK1NAMPTMAPTKDM4EALDH1A1
SCHEMBL23704277 0.81 MAPT (0.43) MAPTKDM4EALDH1A1L3MBTL1
SCHEMBL23704194 0.80 NAMPT (0.37) MAPK1NAMPTMAPTKDM4EALDH1A1
SCHEMBL29994245 0.80 NAMPT (0.37) MAPK1NAMPTMAPTKDM4EALDH1A1
SCHEMBL23707340 0.80 MAPT (0.38) MAPK1NAMPTMAPTKDM4EALDH1A1
SCHEMBL23707385 0.80 RAB9A (0.37) MAPK1NAMPTMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115052860-B Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2024-06-21 — — CN disclosed
EP-4097084-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2022-12-07 — — EP disclosed
CN-115052860-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-09-13 — — CN disclosed
WO-2021154902-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-08-05 — — WO disclosed
WO-2021154902-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-08-05 — — WO disclosed
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