Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496383 | 0.81 | IDO1 (0.44) | KDM4EKCNQ3KCNQ2DHFRMAPT | |
| SCHEMBL20129875 | 0.79 | KCNQ2 (0.50) | KDM4EKCNQ3KCNQ2MAPTSMN1; SMN2 | |
| SCHEMBL20129870 | 0.77 | KCNQ3 (0.43) | KDM4EKCNQ3KCNQ2MAPTSMN1; SMN2 | |
| SCHEMBL23134838 | 0.71 | P2RX7 (0.43) | KDM4EMAPTADRA2BP2RX7GAA | |
| SCHEMBL17749207 | 0.69 | KCNQ3 (0.56) | KDM4EKCNQ3KCNQ2MAPTSMN1; SMN2 | |
| SCHEMBL20129861 | 0.69 | BACE1 (0.46) | KDM4EKCNQ3KCNQ2MAPTSMN1; SMN2 | |
| SCHEMBL21649888 | 0.69 | KDM4E (0.44) | KDM4EP2RX7ALDH1A1 | |
| SCHEMBL20831858 | 0.67 | SLC6A4 (0.44) | P2RX7HSP90B1TRAP1HSP90AA1 | |
| SCHEMBL9683520 | 0.67 | TRPM5 (0.43) | SMN1; SMN2ADRA2BTDP1TSHRL3MBTL1 | |
| SCHEMBL28870158 | 0.67 | MAPT (0.68) | KDM4EMAPTSMN1; SMN2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | KCNH3, KCNH2, KCNJ11 | KDM4E 1137/4885KCNQ3 43/4885KCNQ2 35/4885 |
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | KDM4E 1137/4885KCNQ3 43/4885KCNQ2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.