Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14379252 | 0.86 | DGAT1 (1.00) | DGAT1ESR1ESR2 | |
| SCHEMBL9769490 | 0.67 | KDM4E (0.40) | DGAT1ESR1ESR2 | |
| SCHEMBL7760470 | 0.67 | KDM4E (0.40) | DGAT1ESR1ESR2 | |
| SCHEMBL14379253 | 0.66 | DGAT1 (0.74) | DGAT1MAP4K4TNK2CHEK1AURKA | |
| SCHEMBL4649359 | 0.57 | PDE3B (0.71) | — | |
| SCHEMBL1784311 | 0.56 | HPGD (0.60) | MAP4K4TNK2KDRGSK3B | |
| SCHEMBL24756807 | 0.56 | ALDH1A1 (0.50) | — | |
| SCHEMBL23676541 | 0.55 | HRH2 (0.37) | CSNK1A1CLK4 | |
| SCHEMBL4006982 | 0.55 | ALDH1A1 (0.40) | — | |
| SCHEMBL18131123 | 0.55 | KDM4E (0.48) | MAP4K4TNK2DAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3366686-B9 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | METABASIS THERAPEUTICS INC (US) | 2021-08-04 | — | — | EP | disclosed |