Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26154311 | 0.89 | FAAH (0.52) | FAAHPSMB5EPHX2PTPN1 | |
| SCHEMBL26154325 | 0.89 | FAAH (0.52) | FAAHPSMB5EPHX2PTPN1 | |
| SCHEMBL25497019 | 0.88 | FAAH (0.60) | FAAHPSMB5CTSBEPHX2CHRNB2 | |
| SCHEMBL26346709 | 0.88 | PSMB5 (0.50) | FAAHPSMB5CTSBCHRNB2CHRNB4 | |
| SCHEMBL25148144 | 0.87 | FAAH (0.56) | FAAHPSMB5CTSBEPHX2CHRNB2 | |
| SCHEMBL24982484 | 0.87 | FAAH (0.50) | FAAHPSMB5EPHX2CHRNB2CHRNB4 | |
| SCHEMBL24577164 | 0.86 | FAAH (0.49) | FAAHPSMB5EPHX2PTPN1 | |
| SCHEMBL27109780 | 0.85 | CHRNB2 (0.52) | FAAHPSMB5CTSBCHRNB2CHRNB4 | |
| SCHEMBL24982489 | 0.84 | FAAH (0.69) | FAAHPSMB5EPHX2 | |
| SCHEMBL27117604 | 0.84 | PSMB5 (0.48) | FAAHPSMB5CTSBCHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858386-A1 | LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |