Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 4/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406597 | 0.95 | DHODH (0.50) | PLA2G2ATRPV4MITFAKR1C3AKR1C2 | |
| SCHEMBL2372795 | 0.93 | PTGFR (0.45) | PLA2G2ATRPV4PTGFRDHODHKDM4E | |
| SCHEMBL2372251 | 0.92 | TRPV4 (0.51) | PLA2G2ATRPV4AKR1C3AKR1C2TDP1 | |
| SCHEMBL2373306 | 0.92 | DHODH (0.51) | PLA2G2ATRPV4PTGFRDHODHKDM4E | |
| SCHEMBL2372472 | 0.89 | PLA2G2A (0.51) | PLA2G2ATRPV4PTGFRDHODHKDM4E | |
| SCHEMBL2372559 | 0.88 | TRPV4 (0.50) | TRPV4PTGFRDHODHKDM4ESMN1; SMN2 | |
| SCHEMBL2373029 | 0.87 | DHODH (0.57) | PLA2G2AMITFPLGPLAUPLAT | |
| SCHEMBL2372765 | 0.86 | PTGS2 (0.43) | TRPV4PTGFRDHODHKDM4EMEN1 | |
| SCHEMBL2373287 | 0.84 | TRPV4 (0.52) | TRPV4TDP1KDM4EMEN1KMT2A | |
| SCHEMBL2372142 | 0.84 | CTSA (0.44) | TRPV4PTGFRMAPK14MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |