Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | PTGFR | P43088 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373396 | 0.87 | PLA2G2A (0.48) | DHODHPLA2G2ANOTUMKDM4EGAA | |
| SCHEMBL2373435 | 0.84 | DHODH (0.57) | DHODHPLA2G2APTGFRKDM4EMAPT | |
| SCHEMBL2372690 | 0.76 | TRPV4 (0.51) | — | |
| SCHEMBL2373092 | 0.76 | KDM4E (0.56) | DHODHPLA2G2APTGFRKDM4EMAPT | |
| SCHEMBL2372781 | 0.75 | PLA2G2A (0.63) | DHODHPLA2G2APTGFRKDM4EGAA | |
| SCHEMBL2373208 | 0.74 | DHODH (0.61) | DHODHPTGFR | |
| SCHEMBL2372070 | 0.74 | DHODH (0.65) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL14553163 | 0.73 | DHODH (0.59) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL2371993 | 0.73 | DHODH (0.59) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL2373101 | 0.73 | MAPT (0.69) | DHODHPLA2G2APTGFRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |