Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29955399 | 0.65 | ERN1 (0.41) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9764609 | 0.64 | KDM4E (0.43) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL1150001 | 0.62 | REN (0.39) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4784077 | 0.60 | HTT (0.35) | MEN1KMT2ATRIM24TRIM33SMN1; SMN2 | |
| SCHEMBL5430679 | 0.60 | ALDH1A1 (0.54) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL29072818 | 0.60 | L3MBTL1 (0.37) | KDM4EHSP90AA1L3MBTL1NPC1LMNA | |
| SCHEMBL31298618 | 0.60 | PDE1A (0.40) | KDM4EHSP90AA1L3MBTL1NPC1IDO1 | |
| SCHEMBL29935771 | 0.60 | ALDH1A1 (0.54) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15273710 | 0.60 | KMT2A (0.46) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 | |
| SCHEMBL3409403 | 0.60 | KDM4E (0.56) | KDM4EHSP90AA1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |