SCHEMBL23728718

SCHEMBL23728718

COC(=O)c1cc(NC(=O)c2nc(NC(=O)CCN)cn2C)cn1C

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.49
HDAC2 Q92769 2/20 0.49
HDAC8 Q9BY41 2/20 0.49
ERBB2 P04626 14/20 0.42
P2RY12 Q9H244 1/20 0.39
TOP1 P11387 2/20 0.38
HRAS P01112 1/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
KDM4E B2RXH2 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
HIF1A Q16665 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL23728721 0.99 HDAC1 (0.49) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL25197886 0.94 HDAC1 (0.57) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL31614489 0.87 HDAC1 (0.40) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL23744936 0.87 HDAC1 (0.56) HDAC1HDAC2HDAC8ERBB2TOP1
SCHEMBL30693783 0.85 HDAC1 (0.61) HDAC1HDAC2HDAC8ERBB2TOP1
SCHEMBL27346942 0.85 HDAC1 (0.57) HDAC1HDAC2HDAC8ERBB2TOP1
SCHEMBL25696107 0.85 HDAC1 (0.58) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL24510731 0.85 HDAC1 (0.54) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL24510736 0.84 HDAC1 (0.55) HDAC1HDAC2HDAC8ERBB2P2RY12
SCHEMBL23728604 0.84 HDAC1 (0.55) HDAC1HDAC2HDAC8ERBB2P2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250368628-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES DESIGN THERAPEUTICS INC (US) 2025-12-04 US disclosed
US-20250295632-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. 2025-09-25 US disclosed
EP-4539842-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES Design Therapeutics, Inc. (US) 2025-04-23 EP disclosed
EP-4539839-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES Design Therapeutics, Inc. (US) 2025-04-23 EP disclosed
US-20250109132-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA DESIGN THERAPEUTICS INC (US) 2025-04-03 US disclosed
EP-4522168-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2025-03-19 EP disclosed
EP-4460302-A2 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2024-11-13 EP disclosed
US-20240360105-A1 PROCESS FOR POLYAMIDE SYNTHESIS Design Therapeutics, Inc. 2024-10-31 US disclosed
EP-4384506-A1 PROCESS FOR POLYAMIDE SYNTHESIS Design Therapeutics, Inc. (US) 2024-06-19 EP disclosed
US-20240166693-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPY 1 Design Therapeutics, Inc. 2024-05-23 US disclosed
US-20230149550-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-05-18 US disclosed
US-20230149550-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-05-18 US disclosed
WO-2023014793-A1 PROCESS FOR POLYAMIDE SYNTHESIS Design Therapeutics, Inc. (US) 2023-02-09 WO disclosed
EP-4100404-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. (US) 2022-12-14 EP disclosed
WO-2022150555-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2022-07-14 WO disclosed
WO-2022150555-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2022-07-14 WO disclosed
WO-2022126000-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 Design Therapeutics, Inc. (US) 2022-06-16 WO disclosed
WO-2022126000-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 Design Therapeutics, Inc. (US) 2022-06-16 WO disclosed
WO-2021158707-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. (US) 2021-08-12 WO disclosed
WO-2021158707-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. (US) 2021-08-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230149550-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE DMPK, DTYMK, MYCBP HDAC1 551/4885HDAC2 1636/4885HDAC8 441/4885
US-20240166693-A1 METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPY 1 MTPN, DMPK, MBNL1 HDAC1 658/4885HDAC2 1728/4885HDAC8 463/4885
US-20240360105-A1 PROCESS FOR POLYAMIDE SYNTHESIS POLI, POLR2A, POLR2B HDAC1 489/4885HDAC2 551/4885HDAC8 156/4885
US-20250368628-A1 METHODS AND COMPOUNDS FOR MODULATING INHERITED GENETIC DISEASES CLN6, GATAD2B, MITF HDAC1 486/4885HDAC2 885/4885HDAC8 291/4885
US-20250295632-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA ATXN2, CLN6, ATXN2L HDAC1 844/4885HDAC2 585/4885HDAC8 225/4885
US-20250109132-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA ATXN2, ATXN2L, ATXN10 HDAC1 569/4885HDAC2 1062/4885HDAC8 202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.