Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740633 | 0.87 | MAPT (0.53) | MAPTSIRT5KMT2APIN1HTR6 | |
| SCHEMBL3952581 | 0.85 | POLB (0.56) | MAPTNPC1RAB9ASIRT5PKM | |
| SCHEMBL15740611 | 0.84 | MAPT (0.49) | MAPTNPC1RAB9ASIRT5PKM | |
| SCHEMBL15740729 | 0.77 | L3MBTL1 (0.53) | MAPTNPC1PKMPOLBSMN1; SMN2 | |
| SCHEMBL14841617 | 0.77 | PIN1 (0.62) | MAPTNPC1RAB9ASIRT5KMT2A | |
| SCHEMBL4002405 | 0.77 | L3MBTL1 (0.58) | MAPTPKMKMT2APIN1POLB | |
| SCHEMBL3449318 | 0.76 | PGK1 (0.48) | MAPTPKMSMN1; SMN2 | |
| SCHEMBL30578486 | 0.76 | LMNA (0.65) | MAPTNPC1RAB9APKMKMT2A | |
| SCHEMBL103245 | 0.76 | KMT2A (0.63) | MAPTNPC1RAB9APKMKMT2A | |
| SCHEMBL16489562 | 0.76 | CTSB (0.57) | MAPTPKMKMT2APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100404-A1 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158707-A1 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. (US) | 2021-08-12 | — | — | WO | disclosed |