Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 4/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26700931 | 0.91 | DRD2 (0.41) | GNAI3GNAO1GNAI1DRD2DRD3 | |
| SCHEMBL23729306 | 0.80 | HTR7 (0.39) | DRD3HTR7NPC1 | |
| SCHEMBL23729789 | 0.79 | ALDH1A1 (0.40) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL23729441 | 0.78 | HTR1A (0.38) | DRD2DRD3PAOXHTR7NPC1 | |
| SCHEMBL26700936 | 0.78 | HTR1A (0.38) | DRD2DRD3PAOXHTR7 | |
| SCHEMBL26700934 | 0.78 | HRH2 (0.40) | DRD2HTR7 | |
| SCHEMBL26700877 | 0.77 | NPC1 (0.38) | GNAI3GNAO1GNAI1NPC1 | |
| SCHEMBL26700879 | 0.76 | ALDH1A1 (0.37) | DRD3HTR7NPC1 | |
| SCHEMBL26700958 | 0.74 | HTR7 (0.34) | DRD3HTR7NPC1 | |
| SCHEMBL26700788 | 0.74 | ALDH1A1 (0.39) | NPC1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |