Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23734784 | 0.86 | ALDH1A1 (0.51) | HTTKMT2ALMNAALDH1A1HRH1 | |
| SCHEMBL22735458 | 0.80 | HCRTR1 (0.48) | KMT2AMEN1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL23716678 | 0.79 | SPR (0.48) | KMT2AMEN1HCRTR1HCRTR2SPR | |
| SCHEMBL596167 | 0.78 | OPRK1 (0.44) | KMT2AMEN1SCD5SPR | |
| SCHEMBL596166 | 0.78 | OPRK1 (0.44) | KMT2AMEN1SCD5SPR | |
| SCHEMBL23734969 | 0.77 | HTT (0.51) | HTTKMT2AMEN1GAA | |
| SCHEMBL22735588 | 0.77 | HTT (0.51) | HTTKMT2AMEN1GAA | |
| SCHEMBL23734850 | 0.77 | SMN1; SMN2 (0.48) | HTTKMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL1032633 | 0.74 | USP30 (0.56) | KMT2AMEN1 | |
| SCHEMBL8248136 | 0.74 | USP30 (0.56) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3594202-B1 | SUBSTITUTED PYRROLIDINE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2021-08-11 | — | — | EP | disclosed |