Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739841 | 0.85 | MAPT (0.53) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739880 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL24818019 | 0.84 | S1PR5 (0.35) | — | |
| SCHEMBL23298801 | 0.81 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL23739741 | 0.81 | ALDH1A1 (0.32) | ALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL23739437 | 0.81 | DRD2 (0.42) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739465 | 0.80 | MAPT (0.51) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739922 | 0.77 | ACKR3 (0.37) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23740087 | 0.77 | NPC1 (0.43) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL20879678 | 0.74 | LMNA (0.41) | ALDH1A1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |