Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739465 | 0.96 | MAPT (0.51) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739657 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739667 | 0.83 | POLB (0.35) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL23739756 | 0.83 | MAPT (0.44) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739841 | 0.82 | MAPT (0.53) | ALDH1A1MAPTLMNANPSR1MEN1 | |
| SCHEMBL23739890 | 0.81 | POLB (0.35) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL24572202 | 0.81 | POLB (0.35) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL23739899 | 0.81 | POLB (0.34) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL23739521 | 0.81 | POLB (0.35) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL23739632 | 0.80 | LMNA (0.36) | ALDH1A1MAPTLMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |