Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739454 | 0.89 | DRD2 (0.52) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL23739848 | 0.89 | DRD2 (0.52) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL23739915 | 0.86 | DRD3 (0.39) | DRD3SLC6A4DRD2DRD4HTR7 | |
| SCHEMBL23739903 | 0.86 | DRD3 (0.37) | DRD3SLC6A2SLC6A4DRD2DRD4 | |
| SCHEMBL23740080 | 0.81 | HTR1A (0.48) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL23739773 | 0.81 | HTR1A (0.41) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL23739613 | 0.81 | ADRA1D (0.43) | HTR1A | |
| SCHEMBL23739736 | 0.81 | HTR1A (0.37) | DRD3DRD2DRD4HTR7HTR1A | |
| SCHEMBL23739690 | 0.80 | DRD2 (0.51) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL23739573 | 0.79 | HTR1A (0.30) | HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |