Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.47 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739454 | 1.00 | DRD2 (0.52) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23739761 | 0.89 | DRD3 (0.40) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23739439 | 0.87 | DRD2 (0.47) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23740080 | 0.81 | HTR1A (0.48) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23739613 | 0.81 | ADRA1D (0.43) | HTR1A | |
| SCHEMBL23739773 | 0.81 | HTR1A (0.41) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23739690 | 0.80 | DRD2 (0.51) | DRD2DRD3HTR2AHTR1AHTR7 | |
| SCHEMBL23739573 | 0.80 | HTR1A (0.30) | HTR1AHTR7 | |
| SCHEMBL23739921 | 0.80 | DRD2 (0.41) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL23739734 | 0.74 | NR1H2 (0.32) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |