Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ESR1 | P03372 | 3/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30789017 | 1.00 | HDAC6 (0.56) | HDAC6SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL30965482 | 0.90 | MAPT (0.54) | HDAC6SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL25045583 | 0.90 | MAPT (0.54) | HDAC6SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL10590678 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL23748387 | 0.86 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL9115618 | 0.86 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL28173331 | 0.85 | HDAC6 (0.62) | HDAC6SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL24106599 | 0.84 | NPC1 (0.73) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL30965463 | 0.84 | NPC1 (0.73) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL30788998 | 0.84 | CETP (0.51) | HDAC6SMN1; SMN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3863755-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | Albert Einstein College of Medicine (US) | 2021-08-18 | — | — | EP | claimed |
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387953-A1 | BENZOXAZOLE AND RELATED COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | CLPX, SQSTM1, ATG7 | HDAC6 67/4885SMN1; SMN2 2666/4885KDM4E 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.