Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373659 | 0.87 | PKM (0.52) | PKMKMT2AMEN1CYP4F2CYP4A11 | |
| SCHEMBL2185229 | 0.87 | CYP4F2 (0.41) | KMT2AMEN1CYP4F2CYP4A11LMNA | |
| SCHEMBL1003120 | 0.87 | LMNA (0.50) | KMT2AMEN1CYP4F2CYP4A11LMNA | |
| SCHEMBL1003394 | 0.86 | MEN1 (0.50) | KMT2AMEN1CYP4F2CYP4A11LMNA | |
| SCHEMBL2375444 | 0.85 | LMNA (0.44) | GPR119PKMKMT2AMEN1CYP4F2 | |
| SCHEMBL2374881 | 0.84 | GPR119 (0.51) | GPR119PKMKMT2AMEN1 | |
| SCHEMBL2468103 | 0.82 | PLA2G10 (0.41) | KMT2AMEN1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL4029213 | 0.75 | LMNA (0.57) | KMT2AMEN1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL23851410 | 0.74 | KMT2A (0.43) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL2469958 | 0.74 | RAB9A (0.46) | GPR119KMT2AMEN1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |
| EP-2544684-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | Janssen Pharmaceutica, N.V. (BE) | 2013-01-16 | — | — | EP | disclosed |
| US-20110224209-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-15 | — | — | US | disclosed |
| WO-2011112685-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224209-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | DPP4, DPP3, DPP7 | GPR119 38/4885PKM 1565/4885KMT2A 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.