Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485621 | 0.83 | AVPR1A (0.44) | MEN1KMT2AALDH1A1CYP3A4MAPT | |
| SCHEMBL2374881 | 0.82 | GPR119 (0.51) | MEN1KMT2ACYP2C19TSHR | |
| SCHEMBL2374888 | 0.82 | GPR119 (0.41) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL3984421 | 0.82 | KMT2A (0.46) | MEN1KMT2AALDH1A1POLBCYP3A4 | |
| SCHEMBL2463164 | 0.81 | NAAA (0.44) | GAACYP2C19CYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL23647399 | 0.74 | ALDH1A1 (0.44) | GAAMEN1KMT2ACYP2C19CYP2C9 | |
| SCHEMBL2702729 | 0.74 | CHRM2 (0.59) | MEN1KMT2ACYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL2700969 | 0.72 | CYP2D6 (0.58) | GAAMEN1KMT2ACYP2C19CYP2C9 | |
| SCHEMBL6135722 | 0.71 | OPRM1 (0.37) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2700039 | 0.71 | PKLR (0.57) | GAAMEN1KMT2ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | Janssen Pharmaceutica, N.V. (BE) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112685-A1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-15 | — | — | WO | disclosed |