Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593133 | 0.90 | GCK (0.35) | GCKMAP3K5LMNAMAPTKMT2A | |
| SCHEMBL21593100 | 0.90 | ACHE (0.38) | GCKHTR6NR1H2MEN1LMNA | |
| SCHEMBL29836487 | 0.90 | ACHE (0.38) | GCKHTR6NR1H2MEN1LMNA | |
| SCHEMBL21593188 | 0.90 | HTR6 (0.35) | GCKHTR6MAP3K5NR1H2 | |
| SCHEMBL21593137 | 0.90 | HTR6 (0.35) | GCKHTR6MAP3K5NR1H2 | |
| SCHEMBL21593181 | 0.89 | HTR6 (0.35) | GCKHTR6NR1H2MEN1LMNA | |
| SCHEMBL21593186 | 0.89 | HTR6 (0.36) | GCKHTR6NR1H2LMNA | |
| SCHEMBL21593182 | 0.85 | HCRTR2 (0.35) | GCKHTR6MAP3K5NR1H2MEN1 | |
| SCHEMBL21593138 | 0.85 | HCRTR2 (0.34) | GCKHTR6CDK9MAP3K5NR1H2 | |
| SCHEMBL21593132 | 0.83 | ACHE (0.40) | GCKHTR6CDK9MAP3K5NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | ROCK1, ROCK2, RHOA | GCK 3395/4885HTR6 2835/4885CDK9 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.