Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29836487 | 0.91 | ACHE (0.38) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL21593100 | 0.91 | ACHE (0.38) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL23762108 | 0.91 | ACHE (0.42) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL23762076 | 0.90 | GCK (0.36) | GCKMAP3K5LMNAMAPTKMT2A | |
| SCHEMBL21593132 | 0.86 | ACHE (0.40) | GCKACHEMAP3K5LMNAHPGD | |
| SCHEMBL21593181 | 0.85 | HTR6 (0.35) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL21593131 | 0.84 | ACHE (0.38) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL23751199 | 0.84 | ALDH1A1 (0.38) | LMNAHPGDALDH1A1HTTNAMPT | |
| SCHEMBL21593076 | 0.84 | ACHE (0.39) | GCKACHELMNAHPGDALDH1A1 | |
| SCHEMBL29836556 | 0.84 | ACHE (0.39) | GCKACHELMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |