Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 5/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770613 | 0.90 | CYP1A2 (0.37) | — | |
| SCHEMBL23770695 | 0.84 | CYP1A2 (0.34) | CDK9CCNT1 | |
| SCHEMBL23770605 | 0.80 | — | — | |
| SCHEMBL23770552 | 0.77 | JAK2 (0.33) | JAK2TYK2CDK9CCNT1 | |
| SCHEMBL23770407 | 0.76 | ADORA2A (0.35) | CDK9CCNT1 | |
| SCHEMBL23770776 | 0.75 | ABL1 (0.38) | CDK9CCNT1 | |
| SCHEMBL23770732 | 0.75 | NOS3 (0.38) | JAK2CDK9CCNT1 | |
| SCHEMBL23770430 | 0.73 | ABL1 (0.33) | JAK2TYK2CDK9CCNT1 | |
| SCHEMBL23770756 | 0.69 | BACE1 (0.36) | — | |
| SCHEMBL23770543 | 0.68 | S1PR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |