Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770773 | 0.83 | ABL1 (0.37) | S1PR1NOS3NOS2 | |
| SCHEMBL23770552 | 0.83 | JAK2 (0.33) | NOS3NOS2KDM4EMEN1NOS1 | |
| SCHEMBL23770544 | 0.80 | S1PR1 (0.33) | S1PR1SYK | |
| SCHEMBL23770405 | 0.80 | PTPN1 (0.31) | NOS3NOS2PTPN1 | |
| SCHEMBL19925400 | 0.77 | HSD11B1 (0.41) | SYKKDM4E | |
| SCHEMBL29464326 | 0.77 | HSD11B1 (0.41) | SYKKDM4E | |
| SCHEMBL23770613 | 0.77 | CYP1A2 (0.37) | S1PR1PTPN1MEN1KMT2ALMNA | |
| SCHEMBL23770695 | 0.75 | CYP1A2 (0.34) | NOS3NOS2KDM4EMEN1NOS1 | |
| SCHEMBL23770732 | 0.74 | NOS3 (0.38) | S1PR1NOS3NOS2SYKLMNA | |
| SCHEMBL23770551 | 0.71 | PTPN1 (0.36) | PTPN1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |