Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770695 | 0.83 | CYP1A2 (0.34) | ADORA2ADYRK1ACCNT1CDK9KDM4E | |
| SCHEMBL23770528 | 0.82 | ADORA2A (0.35) | ADORA2AADORA2BNISCHKDM4EALDH1A1 | |
| SCHEMBL23770430 | 0.82 | ABL1 (0.33) | GSK3BCCNT1CDK9 | |
| SCHEMBL23770552 | 0.80 | JAK2 (0.33) | DYRK1ACCNT1CDK9KDM4E | |
| SCHEMBL29464358 | 0.79 | SCN9A (0.42) | — | |
| SCHEMBL19925022 | 0.79 | SCN9A (0.42) | — | |
| SCHEMBL23770404 | 0.76 | JAK2 (0.32) | CCNT1CDK9 | |
| SCHEMBL23770613 | 0.76 | CYP1A2 (0.37) | ALDH1A1 | |
| SCHEMBL23770776 | 0.76 | ABL1 (0.38) | CCNT1CDK9 | |
| SCHEMBL23770732 | 0.74 | NOS3 (0.38) | DYRK1ACCNT1CDK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |