Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770555 | 0.90 | ADORA2A (0.32) | ADORA2AKDM4EALDH1A1 | |
| SCHEMBL23770680 | 0.84 | CTSA (0.31) | — | |
| SCHEMBL23770590 | 0.83 | ADORA2A (0.35) | ADORA2A | |
| SCHEMBL23770611 | 0.82 | EGLN2 (0.36) | — | |
| SCHEMBL23770407 | 0.82 | ADORA2A (0.35) | ADORA2ANISCHADORA2BKDM4EALDH1A1 | |
| SCHEMBL23770740 | 0.82 | HSD11B1 (0.33) | LRRK2 | |
| SCHEMBL23770542 | 0.81 | MPL (0.34) | — | |
| SCHEMBL23770409 | 0.81 | BACE1 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL23770602 | 0.79 | NOS3 (0.33) | — | |
| SCHEMBL29464484 | 0.78 | HSD11B1 (0.40) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |