Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770744 | 0.93 | RAF1 (0.33) | HCRTR1HCRTR2RAF1BRAFSOS1 | |
| SCHEMBL23770749 | 0.85 | MPL (0.33) | HCRTR1HCRTR2SOS1GRIN2BCLK2 | |
| SCHEMBL23770733 | 0.81 | PDE10A (0.32) | HCRTR1HCRTR2GRIN2BCLK2LRRK2 | |
| SCHEMBL23770454 | 0.80 | PIM1 (0.34) | WDR5PRKCQ | |
| SCHEMBL19925131 | 0.80 | GHSR (0.39) | MAP4K1TACR1TACR3HCRTR1HCRTR2 | |
| SCHEMBL23770643 | 0.80 | ADRB2 (0.37) | MAP4K1RAF1BRAFSOS1WDR5 | |
| SCHEMBL23770787 | 0.80 | PDE10A (0.35) | TACR1 | |
| SCHEMBL23770705 | 0.80 | HRH3 (0.35) | WDR5 | |
| SCHEMBL23770589 | 0.79 | WDR5 (0.31) | WDR5 | |
| SCHEMBL23770621 | 0.79 | PDE10A (0.35) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |