Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770816 | 0.91 | PDE10A (0.35) | PDE10AHCRTR1HCRTR2SCN10ASCN1A | |
| SCHEMBL23770833 | 0.88 | ADRB2 (0.39) | PHGDHMAPK10HSD17B10 | |
| SCHEMBL23770477 | 0.85 | MAPK10 (0.36) | PHGDHHCRTR1HCRTR2SCN10AGRIN2B | |
| SCHEMBL23770749 | 0.82 | MPL (0.33) | PDE10AHCRTR1HCRTR2GRIN2BCLK2 | |
| SCHEMBL19925068 | 0.81 | ROS1 (0.33) | PDE10APHGDHHCRTR1HCRTR2SCN10A | |
| SCHEMBL23770830 | 0.81 | MAP4K1 (0.33) | HCRTR1HCRTR2GRIN2BCLK2LRRK2 | |
| SCHEMBL23770744 | 0.81 | RAF1 (0.33) | HCRTR1HCRTR2GRIN2BCLK2LRRK2 | |
| SCHEMBL23770496 | 0.78 | RAF1 (0.35) | — | |
| SCHEMBL23770812 | 0.76 | HSD11B1 (0.30) | KRAS | |
| SCHEMBL23770598 | 0.73 | ADRB2 (0.43) | MAPTSCN9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |