Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 3/20 | 0.31 |
| ▸ | TACR3 | P29371 | 3/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770489 | 0.89 | HSD11B1 (0.33) | MPLCLK2LRRK2CCNT1GRIN2B | |
| SCHEMBL23770753 | 0.89 | GRIN2B (0.36) | MPLCLK2LRRK2PDE10AGRIN2B | |
| SCHEMBL23770810 | 0.88 | MPL (0.32) | MPLPDE10ACCNT1GRIN2BPRKCA | |
| SCHEMBL23770836 | 0.85 | MPL (0.33) | MPLCLK2LRRK2PRKCAPRKCQ | |
| SCHEMBL23770759 | 0.84 | MPL (0.43) | MPL | |
| SCHEMBL23770654 | 0.81 | RORC (0.40) | KRASALDH1A1 | |
| SCHEMBL23770806 | 0.81 | RBP4 (0.36) | MPLGRIN2B | |
| SCHEMBL19968849 | 0.80 | SCN9A (0.36) | MPLPTGESCLK2LRRK2TACR1 | |
| SCHEMBL23770569 | 0.79 | EPAS1 (0.34) | MPLHSD11B1 | |
| SCHEMBL19970083 | 0.79 | BTK (0.34) | KRASCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |