Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.31 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.31 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770748 | 0.86 | RORC (0.33) | PRKCAPRKCQTTRRORC | |
| SCHEMBL19925059 | 0.84 | PRKCA (0.33) | PRKCAPRKCQTTRGUCY1B2GUCY1A2 | |
| SCHEMBL23770795 | 0.82 | ABL1 (0.34) | RORC | |
| SCHEMBL23770477 | 0.80 | MAPK10 (0.36) | HCRTR1HCRTR2RORC | |
| SCHEMBL23770510 | 0.78 | JAK2 (0.32) | PRKCAPRKCQ | |
| SCHEMBL19970145 | 0.77 | BTK (0.33) | PRKCAPRKCQTTRHCRTR1HCRTR2 | |
| SCHEMBL19970136 | 0.77 | BTK (0.33) | PRKCAPRKCQTTRHCRTR1HCRTR2 | |
| SCHEMBL23770638 | 0.76 | EIF2AK4 (0.31) | — | |
| SCHEMBL19925823 | 0.76 | SCN1A (0.32) | PRKCAPRKCQTTRHCRTR1HCRTR2 | |
| SCHEMBL19925824 | 0.76 | SCN1A (0.32) | PRKCAPRKCQTTRHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |