Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 3/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770833 | 0.86 | ADRB2 (0.39) | MAPK10PHGDHCYP1A2HTR2CHSD17B10 | |
| SCHEMBL23770733 | 0.85 | PDE10A (0.32) | MAPK10GRIN2BTRPV1KRASMAPT | |
| SCHEMBL23770748 | 0.84 | RORC (0.33) | RORCGRIN2B | |
| SCHEMBL19927716 | 0.84 | RORC (0.37) | MAPK10RORCGRIN2BTRPV1KRAS | |
| SCHEMBL23770795 | 0.83 | ABL1 (0.34) | RORCBRAF | |
| SCHEMBL23770780 | 0.80 | PRKCA (0.33) | RORCHCRTR1HCRTR2 | |
| SCHEMBL23770734 | 0.76 | HCRTR1 (0.35) | MAPK10GRIN2BTRPV1KRASMAPT | |
| SCHEMBL19970017 | 0.76 | HCRTR1 (0.35) | MAPK10GRIN2BTRPV1KRASMAPT | |
| SCHEMBL19927763 | 0.76 | HCRTR1 (0.34) | MAPK10RORCGRIN2BTRPV1KRAS | |
| SCHEMBL19927760 | 0.76 | HCRTR1 (0.34) | MAPK10RORCGRIN2BTRPV1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |