Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770651 | 0.91 | RORC (0.38) | PTPN11CNR1CNR2MEN1KMT2A | |
| SCHEMBL23770871 | 0.89 | MEN1 (0.38) | PTPN11CNR1MEN1KMT2AKCNH2 | |
| SCHEMBL23770499 | 0.88 | PTPN11 (0.36) | PTPN11MEN1KMT2AKCNH2RORC | |
| SCHEMBL23770884 | 0.87 | RORC (0.36) | PTPN11MEN1KMT2ARORCHCRTR1 | |
| SCHEMBL23770835 | 0.85 | PTPN11 (0.34) | PTPN11CNR1RETSCN10A | |
| SCHEMBL23770844 | 0.84 | PTPN11 (0.33) | PTPN11CNR1CNR2DGAT1KCNH2 | |
| SCHEMBL23770500 | 0.84 | RORC (0.32) | PTPN11MEN1KMT2ARORC | |
| SCHEMBL19927752 | 0.83 | PTPN11 (0.36) | PTPN11CNR1CNR2MEN1KMT2A | |
| SCHEMBL23770669 | 0.83 | HTR3A (0.40) | PTPN11KCNH2HTR1A | |
| SCHEMBL23770724 | 0.81 | MAP4K1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |