Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 10/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770500 | 0.91 | RORC (0.32) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL23770654 | 0.90 | RORC (0.40) | MEN1KMT2ACNR1HDAC3HDAC4 | |
| SCHEMBL23770499 | 0.90 | PTPN11 (0.36) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL23770884 | 0.89 | RORC (0.36) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL23770868 | 0.89 | PTPN11 (0.37) | MEN1KMT2ACNR1PTPN11KCNH2 | |
| SCHEMBL23770835 | 0.88 | PTPN11 (0.34) | CNR1PTPN11 | |
| SCHEMBL23770844 | 0.88 | PTPN11 (0.33) | CNR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL23770639 | 0.86 | MGLL (0.35) | CNR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL23770475 | 0.84 | L3MBTL1 (0.39) | MEN1KMT2ACNR1MAPK1 | |
| SCHEMBL22338250 | 0.83 | DGAT1 (0.36) | CNR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |