Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 10/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770654 | 0.91 | RORC (0.40) | RORCPTPN11HDAC3HDAC4HDAC1 | |
| SCHEMBL23770499 | 0.90 | PTPN11 (0.36) | RORCPTPN11MAPK3MAPK1HDAC3 | |
| SCHEMBL23770651 | 0.88 | RORC (0.38) | RORCPTPN11KRASBRAFBTK | |
| SCHEMBL19970118 | 0.86 | RORC (0.35) | RORCPTPN11KRASBRAF | |
| SCHEMBL23770739 | 0.86 | CNR2 (0.38) | PTPN11MAPK3MAPK1 | |
| SCHEMBL23770721 | 0.85 | GPBAR1 (0.33) | RORCBTK | |
| SCHEMBL23770730 | 0.85 | RORC (0.32) | RORC | |
| SCHEMBL23770801 | 0.85 | GPBAR1 (0.33) | RORCBTK | |
| SCHEMBL23770892 | 0.85 | RORC (0.35) | RORCPTPN11BRAFBTK | |
| SCHEMBL19970204 | 0.84 | PRKCA (0.41) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |