Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 7/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970089 | 0.90 | BTK (0.36) | PRKCAPRKCQPTPN11EIF2AK4BTK | |
| SCHEMBL23770841 | 0.90 | MEN1 (0.34) | PRKCAPRKCQPTPN11EIF2AK4ACACB | |
| SCHEMBL23770844 | 0.87 | PTPN11 (0.33) | RORCPTPN11 | |
| SCHEMBL23770832 | 0.87 | RBP4 (0.33) | RORCPRKCAPRKCQPTPN11BTK | |
| SCHEMBL19970118 | 0.86 | RORC (0.35) | RORCPTPN11BRAF | |
| SCHEMBL23770654 | 0.86 | RORC (0.40) | RORCPTPN11BTKGPBAR1BRAF | |
| SCHEMBL23770880 | 0.85 | RORC (0.41) | RORCPTPN11BTKBRAF | |
| SCHEMBL23770730 | 0.83 | RORC (0.32) | RORCPRKCAPRKCQGPBAR1 | |
| SCHEMBL23770651 | 0.83 | RORC (0.38) | RORCPTPN11BTKGPBAR1BRAF | |
| SCHEMBL23770801 | 0.83 | GPBAR1 (0.33) | RORCPRKCAPRKCQBTKGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |