Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | GALR2 | O43603 | 1/20 | 0.32 |
| ▸ | GALR1 | P47211 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770606 | 0.92 | ADRB2 (0.43) | CNR2MAPK3MAPK1PTPN11ADRB2 | |
| SCHEMBL23770650 | 0.88 | PTPN11 (0.32) | CNR2MAPK3MAPK1PTPN11 | |
| SCHEMBL23770694 | 0.86 | GALR2 (0.40) | CNR2GALR2GALR1PDE10A | |
| SCHEMBL23770880 | 0.86 | RORC (0.41) | MAPK3MAPK1PTPN11 | |
| SCHEMBL23770433 | 0.83 | PDE10A (0.36) | CNR2GALR2GALR1PDE10A | |
| SCHEMBL23770664 | 0.82 | NPY5R (0.36) | CNR2MAPK1GALR2GALR1PDE10A | |
| SCHEMBL23770453 | 0.81 | CYP1A2 (0.40) | ADRB2GALR2GALR1 | |
| SCHEMBL23770593 | 0.80 | GALR2 (0.33) | GALR2GALR1PDE10A | |
| SCHEMBL23770819 | 0.80 | HTR3A (0.41) | PTPN11ADRB2 | |
| SCHEMBL23770686 | 0.80 | RBP4 (0.35) | CNR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |